Tmod3 Gene Summary [Mouse]
Enables tropomyosin binding activity. Acts upstream of or within actin cytoskeleton organization; erythrocyte development; and positive regulation of mitotic cell cycle phase transition. Located in striated muscle thin filament. Is expressed in several structures, including alimentary system; brain; heart; metanephros; and sensory organ. Orthologous to human TMOD3 (tropomodulin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmod3 |
| Official Name | tropomodulin 3 [Source:MGI Symbol;Acc:MGI:1355315] |
| Ensembl ID | ENSMUSG00000058587 |
| Bio databases IDs | |
| Aliases | tropomodulin 3 |
| Synonyms | Tropomodulin 3, UTMOD |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmod3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tropomodulin
- microtubule binding
- tropomyosin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bleeding
- anemia
- pervasive developmental disorder
role in cell
- differentiation
- migration
- quantity
- apoptosis
- formation
- formation in
- number
- area
- size
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- ruffle
- Mitochondria
- actin filaments
- membrane ruffles
- myofibrils
- m-bands
- Z line
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmod3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- myofibril assembly
- pointed-end actin filament capping
- muscle contraction
- actin filament organization
- erythrocyte development
Cellular Component
Where in the cell the gene product is active
- striated muscle thin filament
- adherens junction
- cytoskeleton
- myofibril
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- tropomyosin binding