Rpf2 Gene Summary [Mouse]
Predicted to enable 5S rRNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); protein localization to nucleolus; and regulation of signal transduction by p53 class mediator. Predicted to be located in chromosome and nucleoplasm. Predicted to be active in nucleolus. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human RPF2 (ribosome production factor 2 homolog). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rpf2 |
| Official Name | ribosome production factor 2 homolog [Source:MGI Symbol;Acc:MGI:1914489] |
| Ensembl ID | ENSMUSG00000038510 |
| Bio databases IDs | |
| Aliases | ribosome production factor 2 homolog |
| Synonyms | 2810470K21Rik, bA397G5.4, BXDC1, ribosome production factor 2 homolog |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rpf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- 5S rRNA binding
- Brix domain
- protein binding
- The Brix domain is found in a number of eukaryotic proteins
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rpf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- ribosomal large subunit biogenesis
- ribosomal large subunit assembly
Cellular Component
Where in the cell the gene product is active
- chromosome
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- 5S rRNA binding
- rRNA binding