Krt80 Gene Summary [Mouse]
Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Predicted to be located in cytoplasm and intermediate filament. Predicted to be active in keratin filament. Is expressed in molar; naris; renal calyx; submandibular gland primordium; and vibrissa. Orthologous to human KRT80 (keratin 80). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Krt80 |
| Official Name | keratin 80 [Source:MGI Symbol;Acc:MGI:1921377] |
| Ensembl ID | ENSMUSG00000037185 |
| Bio databases IDs | |
| Aliases | keratin 80 |
| Synonyms | 1200016G03Rik, 2310041I20Rik, CK-80, K80, Kb2, KB20, keratin 80, Keratin 90, LOC144501 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Krt80 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Intermediate filament protein
Pathways
Biological processes and signaling networks where the Krt80 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- rectal adenocarcinoma
- colorectal carcinomagenesis
- rectum cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- organismal death
- papillary renal cell carcinoma
- papillary renal cell neoplasia
- renal cell cancer
role in cell
- expression in
- apoptosis
- migration
- proliferation
- invasion by
- growth
- phosphorylation in
- 5-fluorouracil resistance
- paclitaxel resistance
- lipogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intermediate filament cytoskeleton
- intermediate filaments
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Krt80 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- keratinization
- intermediate filament organization
Cellular Component
Where in the cell the gene product is active
- keratin filament
- intermediate filament cytoskeleton
- cytosol
Molecular Function
What the gene product does at the molecular level
- structural constituent of epidermis
- protein binding