Snai2 Gene Summary [Mouse]
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and chromatin binding activity. Involved in several processes, including desmosome disassembly; endocardial cushion formation; and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Acts upstream of or within with a positive effect on chromatin organization. Acts upstream of or within several processes, including negative regulation of cell adhesion involved in substrate-bound cell migration; negative regulation of hematopoietic stem cell proliferation; and positive regulation of fat cell differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study Waardenburg syndrome. Human ortholog(s) of this gene implicated in piebaldism. Orthologous to human SNAI2 (snail family transcriptional repressor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Snai2 |
| Official Name | snail family zinc finger 2 [Source:MGI Symbol;Acc:MGI:1096393] |
| Ensembl ID | ENSMUSG00000022676 |
| Bio databases IDs | |
| Aliases | snail family zinc finger 2 |
| Synonyms | SLUG, SLUGH, SLUGH1, SNAIL2, snail family transcriptional repressor 2, snail family zinc finger 2, WS2D |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Snai2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- DNA binding domain
- nucleic acid binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- transcription repression domain
- double-stranded DNA binding
- Zinc-finger double domain
- zinc finger domain
Pathways
Biological processes and signaling networks where the Snai2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- prostate cancer
- metastasis
- glioma formation
- conjunctivitis
- epithelial cancer
- epithelial neoplasia
- cancer
- Alzheimer disease
role in cell
- proliferation
- migration
- quantity
- phosphorylation in
- activation in
- morphology
- expression in
- apoptosis
- invasion by
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- vimentin filaments
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Snai2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- palate development
- positive regulation of fat cell differentiation
- cell migration involved in endocardial cushion formation
- endothelial cell migration
- epithelial to mesenchymal transition involved in endocardial cushion formation
- epithelium development
- chromatin organization
- regulation of osteoblast differentiation
- negative regulation of keratinocyte proliferation
- negative regulation of transcription from RNA polymerase II promoter
- white fat cell differentiation
- sensory perception of sound
- negative regulation of cell adhesion involved in substrate-bound cell migration
- negative regulation of anoikis
- negative regulation of vitamin D receptor signaling pathway
- pigmentation
- negative regulation of vitamin D biosynthetic process
- osteoblast differentiation
- cellular response to ionizing radiation
- regulation of chemokine production
- regulation of tight junction assembly
- regulation of branching involved in salivary gland morphogenesis
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- negative regulation of DNA damage response, signal transduction by p53 class mediator
- aortic valve morphogenesis
- negative regulation of myeloid cell apoptotic process
- neural crest cell development
- cartilage morphogenesis
- regulation of transcription, DNA-dependent
- negative regulation of canonical Wnt receptor signaling pathway
- negative regulation of cell adhesion mediated by integrin
- Notch signaling pathway
- cellular response to epidermal growth factor stimulus
- desmosome disassembly
- epithelial to mesenchymal transition
- hemopoietic stem cell proliferation
- negative regulation of chondrocyte differentiation
- positive regulation of cell migration
- myeloid cell apoptotic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- chromatin binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- E-box binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity