Pacrg Gene Summary [Mouse]
Enables ubiquitin protein ligase binding activity. Involved in flagellated sperm motility. Acts upstream of or within protein localization and spermatid development. Located in several cellular components, including glial cell projection; manchette; and sperm midpiece. Is active in axonemal B tubule inner sheath and sperm flagellum. Is expressed in several structures, including brain; neural ectoderm; otocyst; pancreas trunk epithelium; and spinal cord ventricular layer. Orthologous to human PACRG (parkin coregulated). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pacrg |
| Official Name | PARK2 co-regulated [Source:MGI Symbol;Acc:MGI:1916560] |
| Ensembl ID | ENSMUSG00000037196 |
| Bio databases IDs | |
| Aliases | PARK2 co-regulated |
| Synonyms | 1700008H23Rik, BUG21, GLUP, HAK005771, LOC100912128, PACRG2.1, PARK2 co-regulated, PARK2CRG, parkin coregulated, pf12, RGD1561027 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pacrg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-tubulin binding
- ubiquitin protein ligase binding
- Parkin co-regulated protein
- Hsp70 protein binding
- actin binding
- heat shock protein binding
- G-protein-coupled receptor binding
- alpha-tubulin binding
- protein binding
- chaperone binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
regulated by
- beta-estradiol
- CX3CR1
disease
- autosomal recessive juvenile Parkinson disease type 2
- Alzheimer disease
- insomnia
- human papilloma virus infection
- obesity
- ovarian carcinoma
- epithelial ovarian cancer
- vitamin D deficiency
- major depression
- early-onset Parkinson disease
role in cell
- cell death
- motility
- development
- spermiogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cilia
- perinuclear region
- manchette
- vesicles
- axonemes
- cytosol
- sperm midpiece
- sperm tail
- neurites
- glial cell projections
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pacrg gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatid development
- protein localization
- cellular response to unfolded protein
Cellular Component
Where in the cell the gene product is active
- nucleus
- axonemal microtubule
- sperm midpiece
- cell body
- cytosol
- vesicle
- manchette
- neuron projection
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor binding
- heat shock protein binding
- ubiquitin protein ligase binding
- actin binding
- beta-tubulin binding
- chaperone binding
- Hsp90 protein binding
- alpha-tubulin binding
- Hsp70 protein binding