Hook3 Gene Summary [Mouse]
Predicted to enable several functions, including cytoskeletal protein binding activity; dynein intermediate chain binding activity; and dynein light chain binding activity. Involved in interkinetic nuclear migration; negative regulation of neurogenesis; and protein localization to centrosome. Acts upstream of or within microtubule anchoring at centrosome and neuronal stem cell population maintenance. Located in centriolar satellite; cytoplasm; and pericentriolar material. Is expressed in central nervous system; future brain; and genitourinary system. Orthologous to human HOOK3 (hook microtubule tethering protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hook3 |
| Official Name | hook microtubule tethering protein 3 [Source:MGI Symbol;Acc:MGI:2443554] |
| Ensembl ID | ENSMUSG00000037234 |
| Bio databases IDs | |
| Aliases | hook microtubule tethering protein 3 |
| Synonyms | 5830454D03RIK, AI317159, E330005F07RIK, HK3, hook microtubule-tethering protein 3, LOC286170 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hook3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hook domain-containing proteins superfamily
- microtubule binding
- cytoskeletal protein binding
- HOOK domain
- dynein intermediate chain binding
- dynein light chain binding
- coiled-coil domain
- protein binding
- identical protein binding
- HOOK protein coiled-coil region
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lymphomagenesis
- breast cancer
- organismal death
- metastasis
- osteoarthropathy
- gastric cancer
- primary central nervous system lymphoma
- primary cancer
- central nervous system cancer
role in cell
- proliferation
- apoptosis
- migration
- expression in
- morphology
- distribution
- fragmentation
- invasion by
- organization
- transport
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule aster fraction
- centrosome
- Golgi Apparatus
- cytosol
- medial face of the Golgi apparatus
- cis face of the Golgi apparatus
- cis Golgi networks
- Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hook3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lysosome organization
- endosome organization
- protein transport
- endosome to lysosome transport
- neuronal stem cell maintenance
- interkinetic nuclear migration
- cytoskeleton-dependent intracellular transport
- early endosome to late endosome transport
- negative regulation of neurogenesis
- cytoplasmic microtubule organization
- microtubule anchoring at centrosome
- protein localization to centrosome
- Golgi localization
Cellular Component
Where in the cell the gene product is active
- pericentriolar material
- centrosome
- cis-Golgi network
- cytoplasm
- FHF complex
- centriolar satellite
- HOPS complex
- microtubule
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- dynactin binding
- dynein light intermediate chain binding
- dynein intermediate chain binding
- microtubule binding
- dynein light chain binding