Psmb5 Gene Summary [Mouse]
Enables peptidase activity. Acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process and response to oxidative stress. Part of proteasome core complex. Is expressed in embryo. Orthologous to human PSMB5 (proteasome 20S subunit beta 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psmb5 |
| Official Name | proteasome (prosome, macropain) subunit, beta type 5 [Source:MGI Symbol;Acc:MGI:1194513] |
| Ensembl ID | ENSMUSG00000022193 |
| Bio databases IDs | |
| Aliases | proteasome (prosome, macropain) subunit, beta type 5 |
| Synonyms | 26s Proteasome Beta 5, 26s Proteasome β 5, beta 5 PROTEASOME subunit, Lmp17, LMPX, MB1, proteasome 20S subunit beta 5, proteasome 20S subunit β 5, Proteasome 20S X, proteasome (prosome, macropain) subunit, beta type 5, proteasome (prosome, macropain) subunit, β type 5, Proteasome subunit beta5c, Proteasome subunit β5c, X proteasome subunit, β 5 PROTEASOME subunit |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Psmb5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ntn_hydrolase
- proteasome endopeptidase complex
- endopeptidase
- peptidase
- protein binding
- Proteasome subunit
Pathways
Biological processes and signaling networks where the Psmb5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- proteinuria
- non-insulin-dependent diabetes mellitus
- diffuse large B-cell lymphoma
- precursor B-cell acute lymphoblastic leukemia
- refractory diffuse large B-cell lymphoma
- relapsed acute lymphocytic leukemia
- recurrent diffuse large B cell lymphoma
- acute lymphoblastic leukemia
- hepatocellular carcinoma
- progressive multiple myeloma
role in cell
- expression in
- proliferation
- quantity
- migration
- phosphorylation in
- accumulation in
- cell viability
- apoptosis
- survival
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- centrosome
- cytosol
- nucleoplasm
- clastosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Psmb5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- proteasomal ubiquitin-dependent protein catabolic process
- proteolysis
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- extracellular vesicular exosome
- cytoplasm
- proteasome core complex
- cytosol
- proteasome complex
- proteasome core complex, beta-subunit complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- endopeptidase activity
- threonine-type endopeptidase activity
- peptidase activity