Rubcn Gene Summary [Mouse]
Predicted to enable phosphatidylinositol phosphate binding activity. Predicted to be involved in negative regulation of autophagosome maturation; negative regulation of endocytosis; and negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in early endosome and late endosome. Is expressed in central nervous system and retina. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 15. Orthologous to human RUBCN (rubicon autophagy regulator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rubcn |
| Official Name | RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein [Source:MGI Symbol;Acc:MGI:1915160] |
| Ensembl ID | ENSMUSG00000035629 |
| Bio databases IDs | |
| Aliases | RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein |
| Synonyms | 1700021K19Rik, 5330403K09, KIAA0226, mKIAA0226, RGD1305422, RUBICON, rubicon autophagy regulator, RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein, SCAR15 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rubcn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- domain involved in Ras-like GTPase signaling
- coiled-coil domain
- phosphoinositide 3-kinase regulator
- protein binding
- Putative zinc-RING and/or ribbon
- RUN domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- systemic lupus erythematosus
- autosomal recessive spinocerebellar ataxia type 15
- proteinuria
- interstitial nephritis
- microgliosis
- glomerulonephritis
- spinocerebellar ataxia 15
- memory deficits
role in cell
- expression in
- function
- apoptosis
- survival
- accumulation in
- autophagy in
- accumulation
- maturation
- co-localization
- autophagy by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- nucleoplasm
- early endosomes
- late endosomes
- multivesicular bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rubcn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of endocytosis
- autophagy
- negative regulation of autophagy
- multivesicular body sorting pathway
- phagocytosis
- immune system process
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- early endosome
- intracellular membrane-bounded organelle
- late endosome
- cytosol
- Golgi apparatus
- lysosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding