Ddx23 Gene Summary [Mouse]
Predicted to enable mRNA binding activity. Predicted to be involved in R-loop processing and mRNA splicing, via spliceosome. Predicted to be located in chromatin; nucleolus; and nucleoplasm. Predicted to be part of U4/U6 x U5 tri-snRNP complex; U5 snRNP; and catalytic step 2 spliceosome. Orthologous to human DDX23 (DEAD-box helicase 23). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ddx23 |
| Official Name | DEAD box helicase 23 [Source:MGI Symbol;Acc:MGI:1921601] |
| Ensembl ID | ENSMUSG00000003360 |
| Bio databases IDs | |
| Aliases | DEAD box helicase 23 |
| Synonyms | 3110082M05RIK, 4921506D17Rik, DEAD-box helicase 23, prp28, PRPF28, SNRNP100, U5-100K, U5-100KD |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ddx23 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- helicase superfamily c-terminal domain
- DEAD/DEAH box helicase
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- enzyme
- protein binding
- DEAD-like helicases superfamily
- SR domain
- Helicase conserved C-terminal domain
- RNA helicase
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiovascular disorder
- lung cancer
- liver cancer
- colon cancer
- neurodevelopmental disorder
- congenital bilateral perisylvian polymicrogyria
- severe acute respiratory syndrome
- infection by HIV-1
role in cell
- splicing by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- catalytic step 2 spliceosome
- spliceosomes
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ddx23 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing, via transesterification reactions
- RNA splicing
- cis assembly of pre-catalytic spliceosome
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- catalytic step 2 spliceosome
- U4/U6 x U5 tri-snRNP complex
- U5 snRNP
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- RNA binding
- protein binding
- RNA helicase activity
- mRNA binding
- helicase activity