Nenf Gene Summary [Mouse]
Enables growth factor activity. Involved in negative regulation of appetite. Acts upstream of or within positive regulation of MAPK cascade. Located in endoplasmic reticulum; extracellular space; and mitochondrion. Is expressed in brain; heart; lung; metanephros; and spinal cord. Orthologous to human NENF (neudesin neurotrophic factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nenf |
| Official Name | neuron derived neurotrophic factor [Source:MGI Symbol;Acc:MGI:1913458] |
| Ensembl ID | ENSMUSG00000037499 |
| Bio databases IDs | |
| Aliases | neuron derived neurotrophic factor |
| Synonyms | 1110060M21Rik, CIR2, neudesin neurotrophic factor, neuron derived neurotrophic factor, SCIRP10, SPUF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nenf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cytochrome b5-like Heme/Steroid binding domain
- protein binding
- growth factor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Endoplasmic Reticulum
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nenf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- negative regulation of appetite
- positive regulation of MAPK cascade
Cellular Component
Where in the cell the gene product is active
- extracellular space
- membrane
- mitochondrion
- endomembrane system
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- metal ion binding