Vash2 Gene Summary [Mouse]
Enables actin binding activity and metallocarboxypeptidase activity. Involved in proteolysis. Acts upstream of or within labyrinthine layer blood vessel development; positive regulation of angiogenesis; and syncytium formation by plasma membrane fusion. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in brain; cerebral cortex intermediate zone; cerebral cortex ventricular layer; cortical plate; and hippocampus. Orthologous to human VASH2 (vasohibin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vash2 |
| Official Name | vasohibin 2 [Source:MGI Symbol;Acc:MGI:2444826] |
| Ensembl ID | ENSMUSG00000037568 |
| Bio databases IDs | |
| Aliases | vasohibin 2 |
| Synonyms | B130052G07Rik, RGD1564105, vasohibin 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vash2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- actin binding
- peptidase
- metallocarboxypeptidase
- protein binding
- Vasohibin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- neoplasia
- hepatocellular carcinoma
- liver cancer
- non-insulin-dependent diabetes mellitus
- androgenic alopecia
role in cell
- expression in
- proliferation
- migration
- cell cycle progression
- apoptosis
- tubulation
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vash2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- labyrinthine layer blood vessel development
- proteolysis
- syncytium formation by plasma membrane fusion
- regulation of angiogenesis
- positive regulation of endothelial cell proliferation
- positive regulation of angiogenesis
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- cytoplasm
- cytosol
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- metallocarboxypeptidase activity
- microtubule binding