Vash1 Gene Summary [Mouse]
Enables actin binding activity and metallocarboxypeptidase activity. Involved in proteolysis. Acts upstream of or within labyrinthine layer blood vessel development and negative regulation of angiogenesis. Predicted to be located in apical part of cell; endoplasmic reticulum; and extracellular space. Predicted to be active in cytoplasm. Is expressed in nervous system and retina. Human ortholog(s) of this gene implicated in liver cirrhosis and portal hypertension. Orthologous to human VASH1 (vasohibin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vash1 |
| Official Name | vasohibin 1 [Source:MGI Symbol;Acc:MGI:2442543] |
| Ensembl ID | ENSMUSG00000021256 |
| Bio databases IDs | |
| Aliases | vasohibin 1 |
| Synonyms | D930046M13RIK, G630009D10Rik, KIAA1036, RGD1564082, TTCP 1, VASH, VASOHIBIN, vasohibin 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vash1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin binding
- peptidase
- metallocarboxypeptidase
- protein binding
- Vasohibin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-small cell lung cancer
- colorectal cancer
- survival
- systemic juvenile idiopathic arthritis
regulates
- cisplatin
role in cell
- quantity
- proliferation
- migration
- tubulation
- angiogenesis
- network formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- apical compartment
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vash1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of blood vessel endothelial cell migration
- negative regulation of angiogenesis
- labyrinthine layer blood vessel development
- angiogenesis
- proteolysis
- response to wounding
- regulation of angiogenesis
- negative regulation of endothelial cell proliferation
- regulation of cell cycle
- regulation of cellular senescence
Cellular Component
Where in the cell the gene product is active
- extracellular space
- apical part of cell
- cytoplasm
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- metallocarboxypeptidase activity