Lmf1 Gene Summary [Mouse]

Acts upstream of or within several processes, including chylomicron remnant clearance; positive regulation of lipoprotein lipase activity; and regulation of lipid metabolic process. Located in endoplasmic reticulum membrane. Is expressed in several structures, including 1st branchial arch mandibular component; adipose tissue; central nervous system; liver; and vertebral cartilage condensation. Human ortholog(s) of this gene implicated in familial lipase maturation factor 1 deficiency. Orthologous to human LMF1 (lipase maturation factor 1). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Lmf1
Official Name
lipase maturation factor 1 [Source:MGI Symbol;Acc:MGI:1923733]
Ensembl ID
ENSMUSG00000002279
Bio databases IDs NCBI: 76483 Ensembl: ENSMUSG00000002279
Aliases lipase maturation factor 1
Synonyms 2400010G15RIK, AW822050, C16ORF26, Cld, HMFN1876, JFP11, lipase maturation factor 1, LOC650392, RGD1310180, RP11 161M62, TMEM112, TMEM112A
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lmf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Lipase maturation factor

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • hypertriglyceridemia
  • glioma
  • glioma formation
  • combined lipase deficiency
  • Turner syndrome
  • non-insulin-dependent diabetes mellitus
  • malignant glioma
  • glioma cancer
  • heart failure
  • Klinefelter syndrome
regulated by
regulates

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • endoplasmic reticulum membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Lmf1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • triglyceride metabolic process
  • protein maturation

Cellular Component

Where in the cell the gene product is active
  • endoplasmic reticulum membrane

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.