Slc24a2 Gene Summary [Mouse]
Enables calcium channel activity. Acts upstream of or within several processes, including learning or memory; neuron cellular homeostasis; and regulation of synaptic plasticity. Located in membrane. Is active in postsynapse and presynapse. Is expressed in lens; lens epithelium; and lens fiber. Orthologous to human SLC24A2 (solute carrier family 24 member 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc24a2 |
| Official Name | solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 [Source:MGI Symbol;Acc:MGI:1923626] |
| Ensembl ID | ENSMUSG00000037996 |
| Bio databases IDs | |
| Aliases | solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 |
| Synonyms | 2810021B17Rik, 6330417K15RIK, LOC100128844, NCKX2, solute carrier family 24 member 2, solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc24a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium channel
- calcium, potassium:sodium antiporter
- cytoplasmic loop
- Sodium/calcium exchanger protein
- K+-dependent Na+/Ca+ exchanger related-protein
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- preeclampsia
- breast cancer
- idiopathic scoliosis
- essential tremor
- focal cortical dysplasia of Taylor
regulates
- Ca2+
- Na+
- ion
- protein-protein complex
- K+
role in cell
- homeostasis in
- long term synaptic depression
- long-term potentiation
- homeostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- presynaptic regions
- cell surface
- postsynaptic region
- cellular membrane
- neurites
- photoreceptor inner segments
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc24a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium ion import
- potassium ion transmembrane transport
- ion transmembrane transport
- learning
- memory
- cellular calcium ion homeostasis
- neuron homeostasis
- ion transport
- calcium ion transmembrane transport
- sodium ion transmembrane transport
- long-term synaptic potentiation
- establishment of localization in cell
- long term synaptic depression
Cellular Component
Where in the cell the gene product is active
- photoreceptor inner segment
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium channel activity
- calcium, potassium:sodium antiporter activity
- symporter activity