Neo1 Gene Summary [Mouse]
Enables BMP receptor binding activity; cadherin binding activity; and signaling receptor activity. Involved in trans-synaptic signaling, modulating synaptic transmission. Acts upstream of or within several processes, including myoblast fusion; negative regulation of axon regeneration; and positive regulation of BMP signaling pathway. Located in several cellular components, including cell surface; growth cone; and intracellular vesicle. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Orthologous to human NEO1 (neogenin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Neo1 |
| Official Name | neogenin [Source:MGI Symbol;Acc:MGI:1097159] |
| Ensembl ID | ENSMUSG00000032340 |
| Bio databases IDs | |
| Aliases | neogenin |
| Synonyms | 2610028H22RIK, D930014N22RIK, IGDCC2, Neogenin, neogenin 1, NGN, NTN1R2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Neo1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Neogenin C-terminus
- signaling receptor activity
- Immunoglobulin V-Type
- immunoglobulin domain
- ectodomain
- Purple acid Phosphatase, N-terminal domain
- Immunoglobulin I-set domain
- protein binding
- receptor binding
- Fibronectin type 3 domain
- cytoplasmic domain
- FN3
- transmembrane domain
- Immunoglobulin like
- intracellular domain
- cadherin binding
- transmembrane receptor
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the Neo1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- depressive disorder
- metabolic syndrome X
- atrial fibrillation
- metastasis
- dental caries
- gout
- early missed abortion
- iron overload
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
role in cell
- growth
- expression in
- cell death
- phosphorylation in
- quantity
- proliferation
- activation in
- number
- formation
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- fimbria
- glutaminergic synapse
- intracellular membrane-bounded organelle
- cell surface
- cellular membrane
- vesicles
- Golgi Apparatus
- synaptic membrane
- nucleoplasm
- synaptic vesicles
- growth cone
- membrane rafts
- cell membrane leading edge
- perikaryon
- axons
- callosal axon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Neo1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular iron ion homeostasis
- positive regulation of BMP signaling pathway
- negative regulation of axon regeneration
- neuron migration
- multicellular organismal iron ion homeostasis
- negative regulation of protein secretion
- myoblast fusion
- axon guidance
- regulation of transcription, DNA-dependent
- cell adhesion
- protein secretion
Cellular Component
Where in the cell the gene product is active
- axonal growth cone
- Golgi apparatus
- plasma membrane
- nucleoplasm
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding
- signaling receptor activity
- BMP receptor binding