Sec23ip Gene Summary [Mouse]
Predicted to enable phospholipase activity. Acts upstream of or within acrosome assembly and single fertilization. Located in cis-Golgi network; endoplasmic reticulum exit site; and perinuclear endoplasmic reticulum. Orthologous to human SEC23IP (SEC23 interacting protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sec23ip |
| Official Name | Sec23 interacting protein [Source:MGI Symbol;Acc:MGI:2450915] |
| Ensembl ID | ENSMUSG00000055319 |
| Bio databases IDs | |
| Aliases | Sec23 interacting protein |
| Synonyms | D7Ertd373e, iPLA1A, iPLA1beta, MSTP053, P125, P125A, SEC23 interacting protein, similar to Sec23-interacting protein p125 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sec23ip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sterile alpha motif
- SAM (Sterile alpha motif )
- SAM domain (Sterile alpha motif)
- DDHD domain
- WWE domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- globozoospermia
- chronic lymphocytic leukemia
regulates
- cholesterol
- IL2RA
- collagen
- B4GALT
- Vsvg
role in cell
- morphology
- development
- organization
- abnormal morphology
- steroidogenesis in
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- intracellular membrane-bounded organelle
- perinuclear region
- Golgi Apparatus
- Endoplasmic Reticulum
- ER-to-Golgi intermediate compartment
- cytosol
- reticular perinuclear compartment
- endoplasmic reticulum exit sites
- cis Golgi networks
- transport vesicles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sec23ip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- Golgi organization
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- intracellular membrane-bounded organelle
- ER to Golgi transport vesicle membrane
- cytosol
- ER to Golgi transport vesicle
- Golgi apparatus
- endoplasmic reticulum
- endoplasmic reticulum-Golgi intermediate compartment
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- metal ion binding