Plekhg6 Gene Summary [Mouse]
Predicted to enable GTPase activator activity and guanyl-nucleotide exchange factor activity. Predicted to be located in cell junction and centrosome. Is expressed in liver and testis. Orthologous to human PLEKHG6 (pleckstrin homology and RhoGEF domain containing G6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plekhg6 |
| Official Name | pleckstrin homology domain containing, family G (with RhoGef domain) member 6 [Source:MGI Symbol;Acc:MGI:2682298] |
| Ensembl ID | ENSMUSG00000038167 |
| Bio databases IDs | |
| Aliases | pleckstrin homology domain containing, family G (with RhoGef domain) member 6 |
| Synonyms | ARHGEF46, Gm155, MyoGEF, pleckstrin homology and RhoGEF domain containing G6, pleckstrin homology domain containing, family G (with RhoGef domain) member 6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plekhg6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGEF
- guanyl-nucleotide exchange factor
- PH domain
- protein binding
- Pleckstrin homology-like domain
- Dbl homology domain
- Pleckstrin homology domain
- RhoGEF domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- colorectal adenoma
- colorectal adenoma formation
role in cell
- formation
- activation in
- phosphorylation in
- uptake in
- formation in
- invasion by
- macropinocytosis in
- retraction in
- multinucleation in
- retraction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell junction
- cell periphery
- centrosome
- midbody
- cytosol
- cell membrane leading edge
- central spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plekhg6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
Cellular Component
Where in the cell the gene product is active
- centrosome
- cleavage furrow
- microvillus
- spindle pole
- cytosol
- cell junction
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity
- GTPase activator activity