Slc43a2 Gene Summary [Mouse]
Enables L-leucine transmembrane transporter activity and L-phenylalanine transmembrane transporter activity. Involved in L-leucine transport and phenylalanine transport. Acts upstream of or within L-amino acid transport. Located in basolateral plasma membrane. Is expressed in several structures, including adrenal medulla; metanephros; nephric duct of male; nervous system; and sensory organ. Orthologous to human SLC43A2 (solute carrier family 43 member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc43a2 |
| Official Name | solute carrier family 43, member 2 [Source:MGI Symbol;Acc:MGI:2442746] |
| Ensembl ID | ENSMUSG00000038178 |
| Bio databases IDs | |
| Aliases | solute carrier family 43, member 2 |
| Synonyms | 7630402D21Rik, LAT4, RGD1305819, solute carrier family 43 member 2, solute carrier family 43, member 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc43a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phenylalanine transporter
- isoleucine transporter
- leucine transporter
- L-amino acid transporter
- protein binding
- amino acid transporter
- methionine transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- non-insulin-dependent diabetes mellitus
regulates
- reactive oxygen species
- 3,3'-diiodothyronine
- ligands of SLC43A1 and SLC43A2
- L-amino acid
- L-phenylalanine
- 3-iodo-L-tyrosine
- amino acids
role in cell
- accumulation in
- cell proliferation
- migration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc43a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- isoleucine transport
- neutral amino acid transport
- negative regulation of amino acid transport
- phenylalanine transport
- amino acid transport
- methionine transport
- leucine transport
Cellular Component
Where in the cell the gene product is active
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- L-amino acid transmembrane transporter activity
- protein binding
- L-isoleucine transmembrane transporter activity
- neutral amino acid transmembrane transporter activity
- amino acid transmembrane transporter activity
- L-phenylalanine transmembrane transporter activity
- L-methionine transmembrane transporter activity
- L-leucine transmembrane transporter activity