Fbxl4 Gene Summary [Mouse]
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Acts upstream of or within autophagy of mitochondrion. Predicted to be located in mitochondrial intermembrane space and nuclear speck. Predicted to be part of SCF ubiquitin ligase complex. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 13. Orthologous to human FBXL4 (F-box and leucine rich repeat protein 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Fbxl4 |
| Official Name | F-box and leucine-rich repeat protein 4 [Source:MGI Symbol;Acc:MGI:2140367] |
| Ensembl ID | ENSMUSG00000040410 |
| Bio databases IDs | |
| Aliases | F-box and leucine-rich repeat protein 4 |
| Synonyms | AI836810, FBL4, FBL5, F-box and leucine-rich repeat protein 4, MTDPS13 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fbxl4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- protein phosphatase 1 regulatory subunit 42
- F-box domain superfamily
- Leucine-rich repeat - CC (cysteine-containing) subfamily
- F-box-like
- protein binding activity, bridging
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Moyamoya disease
- mitochondrial DNA depletion syndrome 13
- hereditary disorder
- motor dysfunction or movement disorder
- Leigh syndrome
- kyphosis
- mitochondrial DNA depletion syndrome
role in cell
- expression in
- binding in
- ubiquitination in
- mitophagy in
- destabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- outer membranes
- Mitochondria
- cytosol
- mitochondrial intermembrane space
- mitochondrial outer membrane
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fbxl4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- mitochondrion degradation
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- ubiquitin ligase complex
- nuclear speck
- cytosol
- SCF ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- protein binding