Capza2 Gene Summary [Mouse]
Predicted to enable actin filament binding activity. Predicted to be involved in actin cytoskeleton organization and barbed-end actin filament capping. Located in brush border; cortical cytoskeleton; and membrane. Part of F-actin capping protein complex. Is expressed in nervous system; submandibular gland primordium; thymus primordium; and vibrissa. Orthologous to human CAPZA2 (capping actin protein of muscle Z-line subunit alpha 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Capza2 |
| Official Name | capping protein (actin filament) muscle Z-line, alpha 2 [Source:MGI Symbol;Acc:MGI:106222] |
| Ensembl ID | ENSMUSG00000015733 |
| Bio databases IDs | |
| Aliases | capping protein (actin filament) muscle Z-line, alpha 2 |
| Synonyms | 1110053K06RIK, CAPPA2, capping actin protein of muscle Z-line subunit alpha 2, capping actin protein of muscle Z-line subunit α 2, Capping Protein alpha2, Capping protein α 2, CAPZ, Capz Alpha2, Caza2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Capza2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-actin capping protein alpha subunit
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cortical cytoskeleton
- Extracellular Space
- cellular membrane
- actin cytoskeleton
- Mitochondria
- cytosol
- dendritic spines
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Capza2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- barbed-end actin filament capping
- macromolecular complex assembly
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- brush border
- membrane
- actin cytoskeleton
- cytosol
- extracellular region
- F-actin capping protein complex
- cortical cytoskeleton
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding