Fbxo25 Gene Summary [Mouse]
Predicted to enable actin binding activity. Involved in protein ubiquitination. Located in nucleus. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including genitourinary system; liver; nervous system; sensory organ; and spleen. Orthologous to human FBXO25 (F-box protein 25). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbxo25 |
| Official Name | F-box protein 25 [Source:MGI Symbol;Acc:MGI:1914072] |
| Ensembl ID | ENSMUSG00000038365 |
| Bio databases IDs | |
| Aliases | F-box protein 25 |
| Synonyms | 9130015I06Rik, F-box protein 25, FBX25 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fbxo25 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain superfamily
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Moyamoya disease
- lymphomagenesis
- mantle cell lymphoma
- idiopathic femoral head osteonecrosis
regulated by
- actinomycin D
- etoposide
- IL36G
- PRKCD
role in cell
- apoptosis
- expression in
- ubiquitination in
- degradation in
- aggregation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fbxo25 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- ubiquitin ligase complex
- cytoplasm
- SCF ubiquitin ligase complex
- nucleolus
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- actin binding