Prkg2 Gene Summary [Mouse]
Enables cGMP-dependent protein kinase activity. Involved in cellular hypotonic response and negative regulation of cell volume. Acts upstream of or within circadian regulation of gene expression. Located in plasma membrane. Is expressed in brain; limb segment; lung; and small intestine. Human ortholog(s) of this gene implicated in acromesomelic dysplasia 4 and spondylometaphyseal dysplasia. Orthologous to human PRKG2 (protein kinase cGMP-dependent 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prkg2 |
| Official Name | protein kinase, cGMP-dependent, type II [Source:MGI Symbol;Acc:MGI:108173] |
| Ensembl ID | ENSMUSG00000029334 |
| Bio databases IDs | |
| Aliases | protein kinase, cGMP-dependent, type II |
| Synonyms | AMD4, CGK 2, CGKII, GDPKII, PKG2, PRKGR2, protein kinase cGMP-dependent 2, protein kinase, cGMP-dependent, type II, SMDP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prkg2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cGMP-dependent protein kinase
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- identical protein binding
- Cyclic nucleotide-monophosphate binding domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Cyclic nucleotide-binding domain
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
- CAP_ED
Pathways
Biological processes and signaling networks where the Prkg2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Adrenomedullin signaling pathway
- Cellular Effects of Sildenafil (Viagra)
- Circadian Rhythm Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Ephrin A Signaling
- Gap Junction Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- Sertoli Cell-Sertoli Cell Junction Signaling
- Sperm Motility
- Synaptic Long Term Depression
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acromesomelic dysplasia type 4
- schizophrenia
- idiopathic scoliosis
- Pagnamenta type spondylometaphyseal dysplasia
- disproportionate dwarfism
- human immunodeficiency virus I infection
role in cell
- proliferation
- activation in
- adhesion
- expression in
- differentiation
- phosphorylation in
- formation
- formation in
- cell death
- G1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- perinuclear region
- cellular membrane
- Plasma Membrane
- cytosol
- primary cilia
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prkg2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- tetrahydrobiopterin metabolic process
- protein kinase A signaling cascade
- negative regulation of chloride transport
- positive regulation of chondrocyte differentiation
- protein phosphorylation
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
- cytosol
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- cGMP-dependent protein kinase activity
- protein kinase activity
- mitogen-activated protein kinase binding
- cGMP binding