Pawr Gene Summary [Mouse]
Predicted to enable actin binding activity; enzyme binding activity; and leucine zipper domain binding activity. Involved in several processes, including positive regulation of cellular senescence; positive regulation of hydrogen peroxide-mediated programmed cell death; and regulation of gene expression. Acts upstream of or within several processes, including negative regulation of T cell receptor signaling pathway; negative regulation of lymphocyte proliferation; and positive regulation of amyloid precursor protein biosynthetic process. Located in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and respiratory system. Orthologous to human PAWR (pro-apoptotic WT1 regulator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pawr |
| Official Name | PRKC, apoptosis, WT1, regulator [Source:MGI Symbol;Acc:MGI:2149961] |
| Ensembl ID | ENSMUSG00000035873 |
| Bio databases IDs | |
| Aliases | PRKC, apoptosis, WT1, regulator |
| Synonyms | 2310001G03RIK, PAR4, PRKC, apoptosis, WT1, regulator, pro-apoptotic WT1 regulator |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pawr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-repressor
- LRR-domain binding
- Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins
- protein kinase C binding
- nuclear localization sequence
- enzyme binding
- leucine zipper domain
- protein binding
- selective for apoptosis of cancer cells domain
- protein phosphatase 1 binding
- actin binding
- phosphatase
Pathways
Biological processes and signaling networks where the Pawr gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- neoplasia
- chronic lymphocytic leukemia
- coronary artery disease
- breast cancer
- amyotrophic lateral sclerosis
- hyperplasia
- bladder exstrophy
- attention deficit hyperactivity disorder
- conduct disorder
role in cell
- phosphorylation in
- activation in
- apoptosis
- transcription in
- proliferation
- growth
- cell death
- expression in
- necrosis
- extravasation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- cell periphery
- perinuclear region
- actin cytoskeleton
- Plasma Membrane
- actin filaments
- cytosol
- nuclear bodies
- neurites
- synaptosomes
- chromatin
- perikaryon
- axons
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pawr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic signaling pathway
- positive regulation of amyloid precursor protein biosynthetic process
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of gene expression
- negative regulation of T cell receptor signaling pathway
- negative regulation of B cell proliferation
- negative regulation of fibroblast proliferation
- negative regulation of T cell proliferation
- positive regulation of gene expression
- apoptotic process
- positive regulation of apoptotic process
- positive regulation of cellular senescence
- actin filament bundle assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- actin cytoskeleton
- cytosol
- actin filament
- chromatin
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- transcription corepressor activity
- leucine zipper domain binding
- enzyme binding