Gmds Gene Summary [Mouse]
Enables GDP-mannose 4,6-dehydratase activity. Predicted to be involved in 'de novo' GDP-L-fucose biosynthetic process and Notch signaling pathway. Is active in cytosol. Is expressed in several structures, including alimentary system; ear; nervous system; respiratory system; and skeleton. Human ortholog(s) of this gene implicated in open-angle glaucoma. Orthologous to human GMDS (GDP-mannose 4,6-dehydratase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gmds |
| Official Name | GDP-mannose 4, 6-dehydratase [Source:MGI Symbol;Acc:MGI:1891112] |
| Ensembl ID | ENSMUSG00000038372 |
| Bio databases IDs | |
| Aliases | GDP-mannose 4, 6-dehydratase |
| Synonyms | GDP-mannose 4, 6-dehydratase, GMD, SDR3E1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gmds often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- GDPmannose 4,6-dehydratase
- binding protein
- NADP binding
- NAD dependent epimerase/dehydratase family
- enzyme
- protein binding
- identical protein binding
- GDP-mannose 4,6 dehydratase
- GDP-mannose 4,6-dehydratase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- gout
- open-angle glaucoma
- renal clear cell adenocarcinoma
- renal clear cell cancer
- glaucoma
- diabetic nephropathy
- normal tension glaucoma
- hemorrhoid
- prostatic carcinoma
phenotypes
- abnormal bone structure
- abnormal cranium morphology
- abnormal snout morphology
- decreased CD4-positive NK T cell number
- decreased CD4-positive CD25-positive alpha-beta regulatory T cell number
- decreased CD4-positive alpha beta T cell number
- decreased CD8-positive alpha-beta T cell number
- decreased CD8-positive naive alpha-beta T cell number
- decreased KLRG1+ CD8 alpha beta T cell number
- decreased KLRG1-positive NK cell number
- decreased Ly6C-positive mature NK cell number
- decreased NK cell number
- decreased T-helper cell number
- decreased alpha-beta T cell number
- decreased body length
- decreased bone mineral content
- decreased circulating glucose level
- decreased circulating magnesium level
- decreased dendritic cell number
- decreased effector memory CD8-positive alpha-beta T cell number
- decreased erythrocyte cell number
- decreased hematocrit
- decreased hemoglobin content
- decreased lean body mass
- decreased macrophage cell number
- decreased mature NK cell number
- decreased memory CD4-positive CD25-positive alpha-beta regulatory T cell number
- decreased memory-marker CD4-negative NK T cell number
- decreased memory-marker CD4-positive NK T cell number
- decreased plasmacytoid dendritic cell number
- decreased regulatory T cell number
- decreased transitional stage T2 B cell number
- increased CD4-negative NK T cell number
- increased CD4-positive alpha beta T cell number
- increased CD8-positive alpha-beta T cell number
- increased Ly6C-positive NK T cell number
- increased NK T cell number
- increased circulating alkaline phosphatase level
- increased circulating chloride level
- increased circulating iron level
- increased gamma-delta T cell number
- increased granulocyte number
- increased immature NK cell number
- increased leukocyte cell number
- increased memory CD4-positive CD25-positive alpha-beta regulatory T cell number
- increased memory-marker NK cell number
- increased monocyte cell number
- increased neutrophil cell number
- abnormal body length
- abnormal circulating alkaline phosphatase level
- abnormal circulating chloride level
- abnormal circulating iron level
- abnormal erythrocyte cell number
- abnormal hematocrit
- abnormal hemoglobin content
role in cell
- apoptosis
- formation in
- fucosylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gmds gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Notch signaling pathway
- 'de novo' GDP-L-fucose biosynthetic process
- GDP-mannose metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- NADP+ binding
- GDP-mannose 4,6-dehydratase activity