Reep2 Gene Summary [Mouse]
Enables taste receptor binding activity. Involved in regulation of intracellular transport. Acts upstream of or within protein transport into membrane raft; sensory perception of bitter taste; and sensory perception of sweet taste. Located in endoplasmic reticulum membrane and plasma membrane. Is expressed in central nervous system; eye; ganglia; incisor; and testis. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 72A. Orthologous to human REEP2 (receptor accessory protein 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Reep2 |
| Official Name | receptor accessory protein 2 [Source:MGI Symbol;Acc:MGI:2385070] |
| Ensembl ID | ENSMUSG00000038555 |
| Bio databases IDs | |
| Aliases | receptor accessory protein 2 |
| Synonyms | C5orf19, receptor accessory protein 2, SGC32445, SPG72, SPG72A, SPG72B, Yip2d |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Reep2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TB2/DP1, HVA22 family
- G-protein-coupled receptor binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- cytoplasmic microtubule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Reep2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sweet taste
- sensory perception of bitter taste
- regulation of intracellular transport
- protein transport into membrane raft
- endoplasmic reticulum tubular network organization
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum tubular network
- endoplasmic reticulum
- cytoplasmic microtubule
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- taste receptor binding
- microtubule binding