Retreg1 Gene Summary [Mouse]
Enables endoplasmic reticulum-autophagosome adaptor activity. Involved in negative regulation of neuron apoptotic process. Acts upstream of or within several processes, including collagen catabolic process; macroautophagy; and white fat cell differentiation. Located in cis-Golgi network and endoplasmic reticulum. Is expressed in several structures, including alimentary system; central nervous system; ganglia; metanephros; and reproductive system. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 2B. Orthologous to human RETREG1 (reticulophagy regulator 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Retreg1 |
| Official Name | reticulophagy regulator 1 [Source:MGI Symbol;Acc:MGI:1913520] |
| Ensembl ID | ENSMUSG00000022270 |
| Bio databases IDs | |
| Aliases | reticulophagy regulator 1 |
| Synonyms | 1810015C04Rik, FAM134B, FLJ20152, JK-1, LOC103689968, reticulophagy regulator 1, Retreg1d |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Retreg1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Reticulon
- protein binding activity, bridging
- protein binding
- Arl6IP1_RETR3-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- organismal death
- squamous-cell carcinoma
- squamous cell cancer
- hereditary sensory and autonomic neuropathy type 2B
- hereditary disorder
- venous thromboembolism
- hereditary sensory neuropathy type II
- hereditary sensory and autonomic neuropathy
role in cell
- expression in
- apoptosis
- cell death
- cell viability
- growth
- phosphorylation in
- differentiation
- proliferation
- loss
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- vesicles
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- cis Golgi networks
- nucleoli
- nuclear bodies
- cis Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Retreg1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- white fat cell differentiation
- sensory perception of pain
- collagen catabolic process
- macromitophagy
- endoplasmic reticulum organization
- negative regulation of neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cis-Golgi network
- nuclear body
- endoplasmic reticulum
- nucleolus
Molecular Function
What the gene product does at the molecular level
- protein binding