Itgam Gene Summary [Mouse]
Enables complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Contributes to cargo receptor activity. Involved in several processes, including central nervous system development; complement-mediated synapse pruning; and endocytosis. Acts upstream of or within several processes, including activated T cell proliferation; microglia development; and neutrophil chemotaxis. Located in external side of plasma membrane and nucleus. Part of integrin alphaM-beta2 complex. Is expressed in several structures, including central nervous system; heart; hemolymphoid system; renal interstitium; and yolk sac. Human ortholog(s) of this gene implicated in lupus nephritis; persistent fetal circulation syndrome; and pre-eclampsia. Orthologous to human ITGAM (integrin subunit alpha M). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Itgam |
| Official Name | integrin alpha M [Source:MGI Symbol;Acc:MGI:96607] |
| Ensembl ID | ENSMUSG00000030786 |
| Bio databases IDs | |
| Aliases | integrin alpha M |
| Synonyms | CD11B, CD11B/CD18, Complement Receptor 5, COMPLEMENT receptor type 3, CR3, CR3A, F730045J24Rik, integrin alpha M, integrin subunit alpha M, integrin subunit α M, Integrin α m, ITGAN, Itgm, Ly-40, MAC-1, MAC1A, MO1A, SLEB6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Itgam often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Integrin alpha cytoplasmic region
- cargo receptor activity
- von Willebrand factor (vWF) type A domain
- heat shock protein binding
- von Willebrand factor type A domain
- inserted domain
- protein binding
- alpha1 domain
- alpha M I domain
- Integrin alpha (beta-propellor repeats)
- binding protein
- Integrin alpha
- cytoplasmic domain
- ligand-binding domain
- vWFA
- cytosolic tail domain
- FG-GAP repeat
- heparin binding
- transmembrane receptor
- lectin domain
Pathways
Biological processes and signaling networks where the Itgam gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Caveolar-mediated Endocytosis Signaling
- Complement System
- Ephrin Receptor Signaling
- ERK/MAPK Signaling
- Granulocyte Adhesion and Diapedesis
- HGF Signaling
- IL-12 Signaling and Production in Macrophages
- MSP-RON Signaling Pathway
- PAK Signaling
- Paxillin Signaling
- Rac Signaling
- Regulation of Actin-based Motility by Rho
- Regulation of Cellular Mechanics by Calpain Protease
- Regulation of eIF4 and p70S6K Signaling
- RhoGDI Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- Signaling by Rho Family GTPases
- Tec Kinase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- cancer
- type II collagen-induced arthritis
- acute myeloid leukemia
- early precursor T-cell acute lymphoblastic leukemia
- myocardial infarction
- ischemia
- stroke
- nonalcoholic steatohepatitis
- endometriosis
regulated by
- ethanol
- sirolimus
- diclofenac
- indomethacin
- 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
- ibuprofen
- Immunoglobulin
- PF4
- spermidine
- zymosan
role in cell
- activation
- expression in
- activation in
- phosphorylation in
- generation in
- production in
- quantity
- aggregation
- degradation in
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- secondary granule fractions
- gelatinase granule fractions
- podosome rosette
- cell surface
- Extracellular Space
- cell periphery
- intracellular space
- cellular membrane
- Nucleus
- vesicles
- cell-cell contacts
- granules
- tertiary granule membrane
- specific granule membrane
- plasma membrane extracellular face
- secretory vesicles
- membrane rafts
- cell membrane leading edge
- exosomes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Itgam gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- positive regulation of protein targeting to membrane
- negative regulation of dopamine metabolic process
- cell adhesion
- complement receptor mediated signaling pathway
- receptor-mediated endocytosis
- positive regulation of neutrophil degranulation
- response to mechanical stimulus
- microglial cell activation
- beta-amyloid clearance
- cell adhesion mediated by integrin
- integrin-mediated signaling pathway
- phagocytosis, engulfment
- response to ischemia
- forebrain development
- innate immune response
- response to estradiol stimulus
- ectodermal cell differentiation
- heterotypic cell-cell adhesion
- positive regulation of prostaglandin-E synthase activity
- positive regulation of superoxide anion generation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- alphaM-beta2 integrin complex
- external side of plasma membrane
- integrin complex
- plasma membrane
- tertiary granule membrane
- specific granule membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- complement component C3b binding
- heat shock protein binding
- protein binding
- metal ion binding
- cargo receptor activity
- integrin binding
- beta-amyloid binding