Kpna7 Gene Summary [Mouse]
Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Acts upstream of or within blastocyst development and regulation of gene expression. Located in female germ cell nucleus and spindle. Is expressed in early conceptus; gonad; and liver. Orthologous to human KPNA7 (karyopherin subunit alpha 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kpna7 |
| Official Name | karyopherin alpha 7 (importin alpha 8) [Source:MGI Symbol;Acc:MGI:2141165] |
| Ensembl ID | ENSMUSG00000038770 |
| Bio databases IDs | |
| Aliases | karyopherin alpha 7 (importin alpha 8) |
| Synonyms | Gm1055, IPOA8, karyopherin subunit alpha 7, karyopherin subunit α 7, LOC684620, OZEMA17 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kpna7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Armadillo/beta-catenin-like repeat
- Atypical Arm repeat
- HEAT-like repeat
- importin beta binding domain
- Armadillo/beta-catenin-like repeats
- protein binding
Pathways
Biological processes and signaling networks where the Kpna7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spindle apparatus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kpna7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression
- positive regulation of gene expression
- protein import into nucleus
- NLS-bearing substrate import into nucleus
- blastocyst development
- regulation of gene expression, epigenetic
Cellular Component
Where in the cell the gene product is active
- female germ cell nucleus
- nucleus
- spindle
- cytosol
- NLS-dependent protein nuclear import complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- nuclear localization sequence binding