Larp7 Gene Summary [Mouse]
Enables U6 snRNA binding activity. Involved in RNA processing; regulation of mRNA splicing, via spliceosome; and spermatogenesis. Acts upstream of or within germ cell proliferation; negative regulation of transcription by RNA polymerase II; and positive regulation of G1/S transition of mitotic cell cycle. Located in nucleus. Is expressed in several structures, including central nervous system; gonad; liver; sensory organ; and spleen. Orthologous to human LARP7 (La ribonucleoprotein 7, transcriptional regulator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Larp7 |
| Official Name | La ribonucleoprotein domain family, member 7 [Source:MGI Symbol;Acc:MGI:107634] |
| Ensembl ID | ENSMUSG00000027968 |
| Bio databases IDs | |
| Aliases | La ribonucleoprotein domain family, member 7 |
| Synonyms | ALAZS, C330027G06RIK, D3Wsu161e, DKFZp564K112, HDCMA18P, hLARP7, La ribonucleoprotein 7, transcriptional regulator, PIP7S |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Larp7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- snRNA binding
- RNA recognition motif (RRM) superfamily
- La domain
- RNA recognition motif
- U6 snRNA binding
- protein binding
- RNA binding motif
- LA motif RNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alazami syndrome
- gastric carcinoma
- gastric epithelial cancer
- mental retardation
role in cell
- binding
- synthesis in
- number
- proliferation
- binding in
- acetylation in
- senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Larp7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- box C/D snoRNA 3'-end processing
- RNA splicing
- negative regulation of transcription elongation from RNA polymerase II promoter
- spermatogenesis
- regulation of nuclear mRNA splicing, via spliceosome
- cell differentiation
- mRNA processing
- negative regulation of viral transcription
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- U6 snRNA binding
- RNA binding
- protein binding
- mRNA binding