Hrh3 Gene Summary [Mouse]
Predicted to enable several functions, including amine binding activity; histamine receptor activity; and neurotransmitter receptor activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; learning or memory; and regulation of secretion. Predicted to be active in dendrite; plasma membrane; and synapse. Is expressed in brain. Orthologous to human HRH3 (histamine receptor H3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hrh3 |
| Official Name | histamine receptor H3 [Source:MGI Symbol;Acc:MGI:2139279] |
| Ensembl ID | ENSMUSG00000039059 |
| Bio databases IDs | |
| Aliases | histamine receptor H3 |
| Synonyms | Eae8, GPCR97, H3, H3R, H3 Receptor, HH3R, histamine H3 receptor, histamine receptor H3, HR3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hrh3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- histamine receptor
- binding protein
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Hrh3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- imetit
- iodophenpropit
- ciproxifan
- impentamine
- R-alpha methylhistamine
- clobenpropit
- ABT-288
- tesmilifene
- buclizine
- triprolidine
disease
- cough
- nausea
- breast cancer
- schizophrenia
- obstructive sleep apnea
- narcolepsy type 2
- narcolepsy with cataplexy
- daytime sleepiness
- narcolepsy
- vomiting
role in cell
- production in
- proliferation
- differentiation
- polymerization in
- elevation in
- flux in
- excitatory glutamatergic input in
- chemotaxis
- hyperpolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hrh3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- synaptic transmission
- neurotransmitter secretion
Cellular Component
Where in the cell the gene product is active
- dendrite
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- histamine receptor activity
- G-protein coupled acetylcholine receptor activity
- serotonin receptor activity