HRH3 Gene Summary [Human]
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | HRH3 |
| Official Name | histamine receptor H3 [Source:HGNC Symbol;Acc:HGNC:5184] |
| Ensembl ID | ENSG00000101180 |
| Bio databases IDs | |
| Aliases | histamine receptor H3 |
| Synonyms | Eae8, GPCR97, H3, H3R, H3 Receptor, HH3R, histamine H3 receptor, histamine receptor H3, HR3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HRH3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- histamine receptor
- binding protein
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the HRH3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- imetit
- iodophenpropit
- ciproxifan
- impentamine
- R-alpha methylhistamine
- clobenpropit
- ABT-288
- tesmilifene
- buclizine
- triprolidine
disease
- cough
- nausea
- breast cancer
- schizophrenia
- obstructive sleep apnea
- narcolepsy type 2
- narcolepsy with cataplexy
- daytime sleepiness
- narcolepsy
- vomiting
role in cell
- production in
- proliferation
- differentiation
- polymerization in
- elevation in
- flux in
- excitatory glutamatergic input in
- chemotaxis
- hyperpolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HRH3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- synaptic transmission
- neurotransmitter secretion
Cellular Component
Where in the cell the gene product is active
- dendrite
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- histamine receptor activity
- G-protein coupled acetylcholine receptor activity
- serotonin receptor activity