Adrb3 Gene Summary [Mouse]
Enables beta-3 adrenergic receptor binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including brown fat cell differentiation; diet induced thermogenesis; and norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure. Located in membrane. Is expressed in central nervous system; early conceptus; oocyte; and retina. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); arthritis (multiple); dilated cardiomyopathy 1H; metabolic dysfunction-associated steatotic liver disease; and type 2 diabetes mellitus. Orthologous to human ADRB3 (adrenoceptor beta 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adrb3 |
| Official Name | adrenergic receptor, beta 3 [Source:MGI Symbol;Acc:MGI:87939] |
| Ensembl ID | ENSMUSG00000031489 |
| Bio databases IDs | |
| Aliases | adrenergic receptor, beta 3 |
| Synonyms | Adrab3, ADRB, adrenergic receptor, beta 3, adrenergic receptor, β 3, adrenoceptor beta 3, adrenoceptor β 3, beta-3 adrenergic receptor, Beta3 adrenoceptor, BETA3AR, β-3 adrenergic receptor, β 3-AR, β(3)AR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adrb3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- hormone binding
- binding protein
- G-protein-coupled receptor binding
- intracellular domain
- protein homodimerization
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- PXXP motif
- beta3-adrenergic receptor
- seven-transmembrane G protein-coupled receptor superfamily
- beta-adrenergic receptor
Pathways
Biological processes and signaling networks where the Adrb3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Breast Cancer Regulation by Stathmin1
- Cardiac Hypertrophy Signaling
- Cellular Effects of Sildenafil (Viagra)
- CREB Signaling in Neurons
- G-Protein Coupled Receptor Signaling
- Gαs Signaling
- Mitochondrial Dysfunction
- Molecular Mechanisms of Cancer
- Myc Mediated Apoptosis Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- Phagosome Formation
- Serotonin Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric cancer
- metastatic gastric cancer
- cancer
- infection
- metastasis
- neoplasia
- thyroid gland neoplasm
- Huntington disease
- major depression
- asthma
role in cell
- expression in
- induction in
- production in
- differentiation
- activation
- phosphorylation in
- quantity
- cellular infiltration by
- accumulation in
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adrb3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of multicellular organism growth
- generation of precursor metabolites and energy
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- energy reserve metabolic process
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- positive regulation of MAPK cascade
- receptor-mediated endocytosis
- negative regulation of G-protein coupled receptor protein signaling pathway
- diet induced thermogenesis
- vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
- eating behavior
- carbohydrate metabolic process
- brown fat cell differentiation
- response to cold
- heat generation
- adenylate cyclase-activating adrenergic receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- epinephrine binding
- protein homodimerization activity
- protein binding
- beta3-adrenergic receptor activity
- beta-adrenergic receptor activity
- norepinephrine binding
- beta-3 adrenergic receptor binding