Akna Gene Summary [Mouse]
Predicted to enable DNA binding activity. Involved in several processes, including epithelial to mesenchymal transition; neuroblast delamination; and neuroblast division in subventricular zone. Located in centriole; centrosome; and microtubule. Is expressed in genitourinary system; hemolymphoid system; nervous system; respiratory system; and sensory organ. Orthologous to human AKNA (AT-hook transcription factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Akna |
| Official Name | AT-hook transcription factor [Source:MGI Symbol;Acc:MGI:2140340] |
| Ensembl ID | ENSMUSG00000039158 |
| Bio databases IDs | |
| Aliases | AT-hook transcription factor |
| Synonyms | AT-hook transcription factor, FLJ31001, LOC158267 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Akna often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- AT-hook-containing transcription factor
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- non-insulin-dependent diabetes mellitus
- liver cancer
- hepatocellular carcinoma
- medulloblastoma
- brain cancer
- acute myeloid leukemia
- liver disease
- nonalcoholic fatty liver disease
- infection by fungus
role in cell
- delamination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- intracellular membrane-bounded organelle
- centrosome
- centriole
- microtubules
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Akna gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuroblast division in subventricular zone
- delamination
- neuroblast delamination
- epithelial to mesenchymal transition
- regulation of inflammatory response
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- centrosome
- centriole
- intracellular membrane-bounded organelle
- membrane
- cytosol
- fibrillar center
- microtubule
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding