Atp6v0e2 Gene Summary [Mouse]
Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in synaptic vesicle lumen acidification. Predicted to be located in clathrin-coated vesicle membrane. Predicted to be part of vacuolar proton-transporting V-type ATPase, V0 domain. Predicted to be active in synaptic vesicle membrane. Is expressed in several structures, including genitourinary system; nervous system; sensory organ; and tongue. Orthologous to human ATP6V0E2 (ATPase H+ transporting V0 subunit e2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp6v0e2 |
| Official Name | ATPase, H+ transporting, lysosomal V0 subunit E2 [Source:MGI Symbol;Acc:MGI:1923502] |
| Ensembl ID | ENSMUSG00000039347 |
| Bio databases IDs | |
| Aliases | ATPase, H+ transporting, lysosomal V0 subunit E2 |
| Synonyms | 0610006O14Rik, ATP6V0E2L, ATPase, H+ transporting, lysosomal V0 subunit E2, ATPase H+ transporting V0 subunit e2, ATPase, H+ transporting V0 subunit e2, C7orf32, CHROMOSOME 7 OPEN READING FRAME 32, NM9.2, V-ATPase V0-e2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atp6v0e2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hydrogen-transporting ATPase activity, rotational mechanism
- enzyme
- ATP synthase subunit H
- ATPase activity, coupled to transmembrane movement of ions
Pathways
Biological processes and signaling networks where the Atp6v0e2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- synaptic vesicle membrane
- lysosome membrane
- endosomal membrane
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atp6v0e2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- regulation of macroautophagy
- vacuolar acidification
Cellular Component
Where in the cell the gene product is active
- vacuolar proton-transporting V-type ATPase, V0 domain
- membrane
- phagocytic vesicle membrane
- endosome membrane
- synaptic vesicle membrane
- lysosomal membrane
- clathrin coated vesicle membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity, coupled to transmembrane movement of ions
- proton-transporting ATPase activity, rotational mechanism