Dyrk1b Gene Summary [Mouse]
Predicted to enable protein serine/threonine kinase activity and transcription coactivator activity. Acts upstream of or within myoblast fusion. Predicted to be located in chromosome and nucleoplasm. Predicted to be active in nucleus. Is expressed in olfactory epithelium. Human ortholog(s) of this gene implicated in abdominal obesity-metabolic syndrome 3. Orthologous to human DYRK1B (dual specificity tyrosine phosphorylation regulated kinase 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dyrk1b |
| Official Name | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b [Source:MGI Symbol;Acc:MGI:1330302] |
| Ensembl ID | ENSMUSG00000002409 |
| Bio databases IDs | |
| Aliases | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b |
| Synonyms | AOMS3, dual specificity tyrosine phosphorylation regulated kinase 1B, MIRK |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dyrk1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase
- subdomain of kinase domain
- protein threonine/tyrosine kinase
- transcription co-activator
- ATP-binding domain
- nuclear localization sequence
- leucine zipper domain
- protein binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- PEST domain
- kinase domain
- Protein Kinases, catalytic domain
- active site
Pathways
Biological processes and signaling networks where the Dyrk1b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- nonalcoholic steatohepatitis
- hypertriglyceridemia
- heart failure
- hepatic steatosis
- hypercholesterolemia
- abdominal obesity-metabolic syndrome 3
- hepatic fibrosis
- fibrosis
role in cell
- expression in
- accumulation in
- survival
- migration
- activation in
- cell viability
- phosphorylation in
- accumulation
- fusion
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dyrk1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- positive regulation of transcription, DNA-dependent
- myoblast fusion
- peptidyl-serine phosphorylation
- protein phosphorylation
- peptidyl-threonine phosphorylation
- adipose tissue development
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- protein serine/threonine/tyrosine kinase activity
- protein binding
- transcription coactivator activity
- protein kinase activity
- protein serine/threonine kinase activity