Alg1 Gene Summary [Mouse]
Predicted to enable chitobiosyldiphosphodolichol beta-mannosyltransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to act upstream of with a positive effect on protein N-linked glycosylation. Predicted to be active in cytoplasmic side of endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ik. Orthologous to several human genes including ALG1 (ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Alg1 |
| Official Name | asparagine-linked glycosylation 1 (beta-1,4-mannosyltransferase) [Source:MGI Symbol;Acc:MGI:2384774] |
| Ensembl ID | ENSMUSG00000039427 |
| Bio databases IDs | |
| Aliases | asparagine-linked glycosylation 1 (beta-1,4-mannosyltransferase) |
| Synonyms | ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase, ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase, ALG1 chitobiosyldiphosphodolichol β-mannosyltransferase, ALG1, chitobiosyldiphosphodolichol β-mannosyltransferase, CDG1K, HMAT1, HMT-1, Mat-1, MT-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Alg1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glycosyltransferase family 1 and related proteins with GTB topology
- chitobiosyldiphosphodolichol beta-mannosyltransferase
- enzyme
- Glycosyl transferases group 1
- Glycosyltransferase Family 4
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congenital disorder of glycosylation type 1k
- congenital disorders of glycosylation
- colorectal cancer
- hereditary disorder
- adenoma formation
- congenital disorder of glycosylation type 1a
- Finnish congenital nephrotic syndrome
- metastasis
- obesity
- aldosterone producing adrenocortical adenoma
regulated by
- metribolone
- beta-estradiol
- medroxyprogesterone acetate
- 8-bromo-cAMP
regulates
- CYP51A1
- oligosaccharide-diphosphodolichol
role in cell
- migration
- invasion by
- endoplasmic reticulum-associated degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Alg1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein glycosylation
- protein N-linked glycosylation
- dolichol-linked oligosaccharide biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- chitobiosyldiphosphodolichol beta-mannosyltransferase activity
- mannosyltransferase activity