Mtmr7 Gene Summary [Mouse]

Enables inositol bisphosphate phosphatase activity. Acts upstream of or within phosphatidylinositol dephosphorylation. Located in cytosol and membrane. Is expressed in several structures, including alimentary system; central nervous system; peripheral nervous system ganglion; sensory organ; and urinary system. Orthologous to human MTMR7 (myotubularin related protein 7). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Nonsense Mediated Decay
Official Symbol
Mtmr7
Official Name
myotubularin related protein 7 [Source:MGI Symbol;Acc:MGI:1891693]
Ensembl ID
ENSMUSG00000039431
Bio databases IDs NCBI: 54384 Ensembl: ENSMUSG00000039431
Aliases myotubularin related protein 7
Synonyms DJ710L4.2, myotubularin related protein 7
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mtmr7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • protein-tyrosine-phoshatase
  • phosphatidylinositol-3-phosphatase
  • inositol bisphosphate phosphatase
  • SET binding domain
  • phosphatase
  • Myotubularin-like phosphatase domain
  • coiled-coil domain
  • PTP_DSP_cys
  • protein binding
  • Pleckstrin homology-like domain

Pathways

Biological processes and signaling networks where the Mtmr7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • COVID-19
  • insomnia
  • spermatocele
  • alloxan-induced diabetic nephropathy
  • myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
regulated by
  • tetrachlorodibenzodioxin
  • lipopolysaccharide
  • CTNNB1
  • ARNT
  • SMO
  • 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate
regulates
  • AKT
  • phosphatidylinositol
  • inositol 1,3-bisphosphate
  • phosphatidylinositol-3-phosphate
role in cell
  • survival

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • membrane fraction
  • perinuclear region
  • cellular membrane
  • cytosol
  • Golgi membrane
  • cytosolic fraction

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Mtmr7 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • protein dephosphorylation
  • phosphatidylinositol biosynthetic process
  • phosphatidylinositol dephosphorylation

Cellular Component

Where in the cell the gene product is active
  • cytoplasm
  • membrane
  • endomembrane system
  • cytosol

Molecular Function

What the gene product does at the molecular level
  • phosphatidylinositol-3-phosphatase activity
  • protein binding
  • protein tyrosine phosphatase activity
  • phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
  • inositol bisphosphate phosphatase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.