Sdk1 Gene Summary [Mouse]
Predicted to enable identical protein binding activity. Acts upstream of or within behavioral response to cocaine and regulation of dendritic spine development. Predicted to be located in plasma membrane. Predicted to be active in synapse. Is expressed in several structures, including gut; liver; metanephros; nervous system; and sensory organ. Orthologous to human SDK1 (sidekick cell adhesion molecule 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sdk1 |
| Official Name | sidekick cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:2444413] |
| Ensembl ID | ENSMUSG00000039683 |
| Bio databases IDs | |
| Aliases | sidekick cell adhesion molecule 1 |
| Synonyms | 5330440E10, 6720466O15RIK, RGD1560686, Sidekick 1, sidekick cell adhesion molecule 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sdk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FN3
- immunoglobulin domain
- Immunoglobulin like
- Purple acid Phosphatase, N-terminal domain
- Immunoglobulin I-set domain
- cytosolic tail domain
- Fibronectin type 3 domain
- PDZ binding motif
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- proteinuria
- liver cancer
- epithelial cancer
- cancer
- insomnia
- anxiety disorder
- stress related disorder
- Alzheimer disease
- depressive disorder
- neuroticism
regulates
role in cell
- aggregation
- morphology
- development
- density
- disorganization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sdk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synapse assembly
- behavioral response to cocaine
- retina layer formation
- regulation of dendritic spine development
- homophilic cell adhesion
Cellular Component
Where in the cell the gene product is active
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding