Rhob Gene Summary [Mouse]

Enables GDP binding activity. Involved in several processes, including positive regulation of angiogenesis; positive regulation of apoptotic process; and regulation of modification of postsynaptic structure. Acts upstream of or within intracellular protein transport. Located in endosome; nucleus; and plasma membrane. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including branchial arch; central nervous system; embryo ectoderm; heart; and sensory organ. Orthologous to human RHOB (ras homolog family member B). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Rhob
Official Name
ras homolog family member B [Source:MGI Symbol;Acc:MGI:107949]
Ensembl ID
ENSMUSG00000054364
Bio databases IDs NCBI: 11852 Ensembl: ENSMUSG00000054364
Aliases ras homolog family member B
Synonyms AA017882, ARH6, ARHB, MST081, MSTP081, ras homolog family member B, Ras homolog gene family, member ab, RAS HOMOLOG GENE family, member B, ras-related homolog B, RHOH6, SEQUENCE 12 FROM PATENT WO9954460
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rhob often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Small GTPase of the Ras superfamily (ill-defined subfamily)
  • Ras family
  • GTPase
  • enzyme
  • protein binding
  • Ras subfamily of RAS small GTPases
  • GTP binding
  • small GTP-binding protein domain
  • GTPase domain
  • GDP binding
  • Rab subfamily of small GTPases
  • Ras of Complex, Roc, domain of DAPkinase
  • Rho (Ras homology) subfamily of Ras-like small GTPases
  • P-loop containing Nucleoside Triphosphate Hydrolases

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • neoplasia
  • metastasis
  • epithelial cancer
  • breast cancer
  • tumorigenesis
  • amyotrophic lateral sclerosis
  • spontaneous abortion
  • T acute lymphoblastic leukemia
  • primary myelofibrosis
  • neoplastic cell transformation
regulated by
regulates
role in cell
  • phosphorylation in
  • accumulation
  • accumulation in
  • activation
  • cell death
  • activation in
  • apoptosis
  • expression in
  • cell rounding
  • recruitment

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • myelin enriched fraction
  • membrane fraction
  • intracellular compartment
  • intracellular space
  • perinuclear region
  • postsynaptic region
  • cellular membrane
  • Nucleus
  • Plasma Membrane
  • endosomes
  • lysosome
  • Golgi Apparatus
  • granules
  • cytosol
  • vesicle membrane
  • endosomal compartment
  • endosomal membrane
  • nuclear rim
  • nuclear envelope
  • synaptic vesicles
  • neurites
  • synapse
  • early endosomes
  • late endosomes
  • multivesicular bodies
  • cleavage furrow
  • perikaryon
  • presynaptic terminals
  • cytosolic fraction

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Rhob gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • signal transduction
  • endothelial tube morphogenesis
  • negative regulation of cell cycle
  • actin filament organization
  • cell adhesion
  • endosome to lysosome transport
  • Rho protein signal transduction
  • intracellular protein transport
  • positive regulation of angiogenesis
  • angiogenesis
  • cytokinesis after mitosis
  • apoptotic process
  • positive regulation of apoptotic process
  • cell differentiation
  • cellular response to ionizing radiation
  • cellular response to hydrogen peroxide
  • regulation of cell migration
  • positive regulation of endothelial cell migration
  • negative regulation of cell migration

Cellular Component

Where in the cell the gene product is active
  • late endosome membrane
  • nucleus
  • early endosome
  • extracellular vesicular exosome
  • focal adhesion
  • cleavage furrow
  • cytosol
  • endosome membrane
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • GTP binding
  • protein binding
  • GTPase activity
  • GDP binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.