Dock3 Gene Summary [Mouse]
Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in small GTPase-mediated signal transduction. Located in cytoplasm. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder. Orthologous to human DOCK3 (dedicator of cytokinesis 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dock3 |
| Official Name | dedicator of cyto-kinesis 3 [Source:MGI Symbol;Acc:MGI:2429763] |
| Ensembl ID | ENSMUSG00000039716 |
| Bio databases IDs | |
| Aliases | dedicator of cyto-kinesis 3 |
| Synonyms | dedicator of cyto-kinesis 3, LOC638531, mKIAA0299, MOCA, NEDIDHA, PBP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dock3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DHR-2, Lobe B
- C2 domain in Dock180 and Zizimin proteins
- Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins
- DHR-2, Lobe A
- guanyl-nucleotide exchange factor
- DOCK homology region 2
- DOCK N-terminus
- protein binding
- Src Homology 3 domain superfamily
- C2 domain
- DHR-2, Lobe C
Pathways
Biological processes and signaling networks where the Dock3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- schizophrenia
- COVID-19
- diverticular disease
- neurodevelopmental disorder with impaired intellectual development, hypotonia, and ataxia
- hereditary disorder
- Alzheimer disease
- insomnia
- asthma
- refractive error
regulated by
- PNPLA2
- budesonide
role in cell
- expression in
- migration
- binding
- cell flattening
- morphology
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- actin filaments
- cytosol
- growth cone
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dock3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nerve growth factor receptor signaling pathway
- small GTPase mediated signal transduction
- regulation of small GTPase mediated signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity
- guanyl-nucleotide exchange factor activity
- small GTPase binding
- SH3 domain binding