Grin2d Gene Summary [Mouse]
Enables NMDA glutamate receptor activity. Involved in regulation of synaptic plasticity. Acts upstream of or within adult locomotory behavior; regulation of sensory perception of pain; and startle response. Located in synapse. Is expressed in brain. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 46. Orthologous to human GRIN2D (glutamate ionotropic receptor NMDA type subunit 2D). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Grin2d |
| Official Name | glutamate receptor, ionotropic, NMDA2D (epsilon 4) [Source:MGI Symbol;Acc:MGI:95823] |
| Ensembl ID | ENSMUSG00000002771 |
| Bio databases IDs | |
| Aliases | glutamate receptor, ionotropic, NMDA2D (epsilon 4) |
| Synonyms | DEE46, EB11, EIEE46, GluN2D, glutamate ionotropic receptor NMDA type subunit 2D, glutamate receptor, ionotropic, NMDA2D (epsilon 4), glutamate receptor, ionotropic, NMDA2D (ε 4), NMDAR2D, NR2D |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Grin2d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Receptor family ligand binding region
- channel/pore class transporter
- calcium channel
- Ligated ion channel L-glutamate- and glycine-binding site
- ionotropic glutamate receptor
- glutamate binding
- extracellular ligand-gated ion channel
- protein binding
- ion channel
- N-methyl-D-aspartate selective glutamate receptor
- neurotransmitter receptor
- cytoplasmic domain
- Type 1 periplasmic binding fold superfamily
- Type 2 periplasmic binding fold superfamily
- ligand-gated ion channel
- cytosolic tail domain
- voltage-gated ion channel
- Bacterial extracellular solute-binding proteins, family 3
- cation channel
Pathways
Biological processes and signaling networks where the Grin2d gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Calcium Signaling
- Circadian Rhythm Signaling
- CREB Signaling in Neurons
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Ephrin Receptor Signaling
- Glutamate Receptor Signaling
- Neuroinflammation Signaling Pathway
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- nNOS Signaling in Neurons
- Opioid Signaling Pathway
- Reelin Signaling in Neurons
- Synaptic Long Term Potentiation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- motion sickness
- COVID-19
- schizophrenia
- early infantile epileptic encephalopathy type 46
- agitation
- tuberculosis
- epilepsy
- treatment resistant depression
- Crohn disease
- traumatic brain injury
role in cell
- depolarization
- response by
- loss
- plasticity
- inactivation in
- action potential in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell periphery
- cellular membrane
- endoplasmic reticulum membrane
- presynaptic membrane
- postsynaptic membrane
- synaptic membrane
- synapse
- axons
- dendrites
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Grin2d gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of excitatory postsynaptic membrane potential
- adult locomotory behavior
- brain development
- startle response
- regulation of neuronal synaptic plasticity
- regulation of synaptic plasticity
- positive regulation of excitatory postsynaptic membrane potential
- long-term synaptic potentiation
- positive regulation of synaptic transmission, glutamatergic
- calcium-mediated signaling
- ionotropic glutamate receptor signaling pathway
- regulation of sensory perception of pain
- synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- postsynaptic membrane
- N-methyl-D-aspartate selective glutamate receptor complex
- presynaptic active zone membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- glutamate-gated calcium ion channel activity
- voltage-gated cation channel activity
- glutamate binding
- ionotropic glutamate receptor activity
- N-methyl-D-aspartate selective glutamate receptor activity