Bnip3l Gene Summary [Mouse]
Enables identical protein binding activity. Involved in regulation of mitophagy and regulation of protein targeting to mitochondrion. Acts upstream of or within positive regulation of apoptotic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human BNIP3L (BCL2 interacting protein 3 like). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bnip3l |
| Official Name | BCL2/adenovirus E1B interacting protein 3-like [Source:MGI Symbol;Acc:MGI:1332659] |
| Ensembl ID | ENSMUSG00000022051 |
| Bio databases IDs | |
| Aliases | BCL2/adenovirus E1B interacting protein 3-like |
| Synonyms | BCL2/adenovirus E1B interacting protein 3-like, BCL2 interacting protein 3 like, Bnip31, BNIP3a, BNIP3H, D14Ertd719e, NIP3L, NIP3-like protein X, NIX, UV93 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bnip3l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-terminal transmembrane domain
- membrane-association domain
- Bcl-2 homology 3 domain
- BNIP3
- transmembrane domain
- lamin binding
- protein homodimerization
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- neoplasia
- metabolic syndrome X
- cardiomyopathy
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- poikilocytosis
- reticulocytosis
- hyperplasia
role in cell
- expression in
- phosphorylation in
- binding in
- growth
- number
- apoptosis
- cell death
- quantity
- differentiation
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- perinucleolar rings
- mitochondrial outer membrane
- nuclear envelope
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bnip3l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial protein catabolic process
- positive regulation of macroautophagy
- negative regulation of mitochondrial membrane potential
- negative regulation of apoptotic process
- positive regulation of apoptotic process
- regulation of programmed cell death
- defense response to virus
- negative regulation of programmed cell death
- cellular response to hypoxia
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nucleus
- nuclear speck
- mitochondrion
- membrane
- endoplasmic reticulum
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein homodimerization activity
- protein binding
- lamin binding