Gk Gene Summary [Mouse]
Enables glycerol kinase activity. Involved in triglyceride biosynthetic process. Acts upstream of or within glucose homeostasis; glycerol metabolic process; and regulation of fatty acid metabolic process. Located in mitochondrion. Is active in cytosol. Is expressed in several structures, including brain; brown fat; genitourinary system; liver; and spleen. Used to study glycerol kinase deficiency. Human ortholog(s) of this gene implicated in glycerol kinase deficiency. Orthologous to several human genes including GK (glycerol kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gk |
| Official Name | glycerol kinase [Source:MGI Symbol;Acc:MGI:106594] |
| Ensembl ID | ENSMUSG00000025059 |
| Bio databases IDs | |
| Aliases | glycerol kinase |
| Synonyms | ASTP, D930012N15RIK, GK1, GKD, Glycerokinase, glycerol kinase, GYK |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- FGGY family of carbohydrate kinases, C-terminal domain
- glycerol kinase
- FGGY family of carbohydrate kinases, N-terminal domain
- enzyme
- protein binding
- ASKHA_ATPase-like
Pathways
Biological processes and signaling networks where the Gk gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- hereditary disorder
- growth failure
- deficiency of glycerol kinase
- hepatic steatosis
- hypoglycemia
- progressive familial intrahepatic cholestasis type 1
regulated by
- LH
- LY294002
- DGKE
- oleic acid
- dexamethasone
- isobutylmethylxanthine
- adenosine triphosphate
- streptozocin
- insulin
- CL 316243
role in cell
- expression in
- phosphorylation in
- activation in
- accumulation in
- mitochondrial respiration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- microsome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycerol metabolic process
- glycerol-3-phosphate biosynthetic process
- triglyceride biosynthetic process
- glycerol catabolic process
- triglyceride metabolic process
- phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- mitochondrion
- cytosol
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- glycerol kinase activity