Ilf3 Gene Summary [Mouse]
The protein encoded by this gene contains two double-stranded RNA binding domains and functions in the post-transcriptional regulation of gene expression. It is a component of an RNA-protein complex that may be involved in mediating the export of messenger RNAs. Alternative splicing results in multiple transcript variants encoding distinct isoforms. These isoforms are grouped into two categories, NFAR-1 or NFAR-2, based on variation at the C-terminus. [provided by RefSeq, Mar 2013]
Details
| Type | Protein Coding |
| Official Symbol | Ilf3 |
| Official Name | interleukin enhancer binding factor 3 [Source:MGI Symbol;Acc:MGI:1339973] |
| Ensembl ID | ENSMUSG00000032178 |
| Bio databases IDs | |
| Aliases | interleukin enhancer binding factor 3 |
| Synonyms | CBTF, DRBF, Interleukin binding factor 3, interleukin enhancer binding factor 3, MBII-26, MMP4, MPHOSPH4, MPP4, MPP4110, NF90, NFAR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ilf3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DZF domain
- transcription regulator
- mRNA 3' UTR binding
- Double-stranded RNA binding motif
- viral receptor
- double-stranded RNA binding motif (DSRM) superfamily
- double-stranded RNA binding
- enzyme binding
- protein binding
- dsRNA-binding domain
- transcription factor activity
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- cyanosis
- systemic lupus erythematosus
- neoplasia
- stroke
- breast cancer
- ischemic stroke
role in cell
- expression in
- transactivation in
- binding in
- apoptosis
- growth
- proliferation
- phosphorylation in
- migration
- survival
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cell surface
- ribosome
- Mitochondria
- cytosol
- nucleoplasm
- nucleoli
- interchromatin granule clusters
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ilf3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- defense response to virus
- protein phosphorylation
- negative regulation of viral genome replication
- negative regulation of translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- mitochondrion
- cytosol
- extracellular region
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA binding
- mRNA 3'-UTR AU-rich region binding
- double-stranded RNA binding
- single-stranded RNA binding
- viral receptor activity