Milr1 Gene Summary [Mouse]
Involved in mast cell degranulation and negative regulation of mast cell activation. Predicted to be located in plasma membrane. Is expressed in adrenal gland; stomach; and testis. Orthologous to human MILR1 (mast cell immunoglobulin like receptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Milr1 |
| Official Name | mast cell immunoglobulin like receptor 1 [Source:MGI Symbol;Acc:MGI:2685731] |
| Ensembl ID | ENSMUSG00000040528 |
| Bio databases IDs | |
| Aliases | mast cell immunoglobulin like receptor 1 |
| Synonyms | Allergin-1, C17orf60, Gm885, LOC284021, mast cell immunoglobulin-like receptor 1, MCA-32 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Milr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C17orf99 Ig domain
- immunoglobulin domain
- Immunoglobulin like
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Milr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- negative regulation of mast cell activation
- cell surface receptor signaling pathway
- mast cell degranulation
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- transmembrane signaling receptor activity