Hmgn1 Gene Summary [Mouse]
Enables chromatin binding activity. Acts upstream of or within several processes, including nucleotide-excision repair; positive regulation of NAD+ ADP-ribosyltransferase activity; and response to UV. Located in female germ cell nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skin. Orthologous to human HMGN1 (high mobility group nucleosome binding domain 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hmgn1 |
| Official Name | high mobility group nucleosomal binding domain 1 [Source:MGI Symbol;Acc:MGI:96120] |
| Ensembl ID | ENSMUSG00000040681 |
| Bio databases IDs | |
| Aliases | high mobility group nucleosomal binding domain 1 |
| Synonyms | high mobility group nucleosomal binding domain 1, high mobility group nucleosome binding domain 1, HMG-14, LOC100911295 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hmgn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- HMG14 and HMG17
- domain in high mobilty group proteins HMG14 and HMG 17
- chromatin binding
- protein binding
- DNA binding
Pathways
Biological processes and signaling networks where the Hmgn1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- benign neoplasia
- cancer
- neoplasia
- metastasis
- advanced cancer
- angiomatosis
- glioma
- glioma formation
- pheochromocytoma formation
- abdominal paraganglioma formation
role in cell
- proliferation
- growth
- G2/M phase
- differentiation
- remodeling
- sensitivity
- survival
- function
- organization
- transcription-coupled nucleotide-excision repair in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hmgn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of development, heterochronic
- post-embryonic camera-type eye morphogenesis
- transcription-coupled nucleotide-excision repair
- response to UV-C
- pyrimidine dimer repair by nucleotide-excision repair
- chromatin organization
- regulation of epithelial cell proliferation
- positive regulation of transcription elongation, DNA-dependent
- response to UV-B
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- female germ cell nucleus
- nucleus
- cytoplasm
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- nucleosomal DNA binding
- chromatin binding