Myt1 Gene Summary [Mouse]
This gene is a member of the myelin transcription factor 1 gene family. The encoded protein, a zinc finger DNA-binding protein, is involved in regulation of oligodendrocyte differentiation and proliferation in the developing central nervous system. The gene product has a role in remyelination through regeneration of oligodendrocyte lineage cells in response to demyelination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
Details
| Type | Protein Coding |
| Official Symbol | Myt1 |
| Official Name | myelin transcription factor 1 [Source:MGI Symbol;Acc:MGI:1100535] |
| Ensembl ID | ENSMUSG00000010505 |
| Bio databases IDs | |
| Aliases | myelin transcription factor 1 |
| Synonyms | C20orf36, MTF1, myelin transcription factor 1, MYTI, NZF2, Nzf2a, Nzf2b, NZTF2, PLPB1, ZC2H2C1, ZC2HC4A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- Myelin transcription factor 1
- transcription regulator
- double-stranded DNA binding
- nucleic acid binding
- Helical region found in SNAREs
- Zinc finger, C2HC type
- protein binding
- SNARE motif
- sequence-specific DNA binding
Pathways
Biological processes and signaling networks where the Myt1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- organismal death
- pervasive developmental disorder
- diverticular disease
- asthma
- movement disorder
- restless legs syndrome
- small cell lung cancer
- mental retardation
- Bell palsy
role in cell
- expression in
- proliferation
- function
- mitotic exit
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cellular membrane
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Myt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell differentiation
- nervous system development
- regulation of transcription, DNA-dependent
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- sequence-specific DNA binding transcription factor activity
- sequence-specific DNA binding RNA polymerase II transcription factor activity