Aipl1 Gene Summary [Mouse]
Predicted to enable farnesylated protein binding activity. Acts upstream of or within several processes, including phototransduction, visible light; regulation of opsin-mediated signaling pathway; and retina homeostasis. Located in photoreceptor inner segment. Used to study Leber congenital amaurosis 4. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; Leber congenital amaurosis 4; blindness; and retinitis pigmentosa. Orthologous to human AIPL1 (aryl hydrocarbon receptor interacting protein like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aipl1 |
| Official Name | aryl hydrocarbon receptor-interacting protein-like 1 [Source:MGI Symbol;Acc:MGI:2148800] |
| Ensembl ID | ENSMUSG00000040554 |
| Bio databases IDs | |
| Aliases | aryl hydrocarbon receptor-interacting protein-like 1 |
| Synonyms | A930007I01Rik, AIPL2, AIP like 1 HSP90 co-chaperone, aryl hydrocarbon receptor-interacting protein-like 1, LCA4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Aipl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- tetratricopeptide repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Leber congenital amaurosis type 4
- Leber congenital amaurosis type 1
- AIPL1-related disorder
- retinal dystrophy
- endometriosis
- AIPL1-related retinopathy
- AIPL1-related juvenile retinitis pigmentosa
- retinitis pigmentosa
- AIPL1-related cone-rod dystrophy
- Leber congenital amaurosis
role in cell
- number
- apoptosis
- abnormal morphology
- formation
- length
- stabilization in
- degeneration
- fragmentation
- disorganization
- electrophysiology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- connecting cilia
- nucleoplasm
- nuclear speckles
- nerve ending
- rod spherules
- photoreceptor inner segments
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Aipl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retina homeostasis
- phototransduction, visible light
- negative regulation of apoptotic process
- apoptotic process
- protein farnesylation
- visual perception
- regulation of rhodopsin mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- cytosol
- photoreceptor inner segment
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- peptidyl-prolyl cis-trans isomerase activity
- protein binding
- unfolded protein binding
- farnesylated protein binding