Ubd Gene Summary [Mouse]
Predicted to enable proteasome binding activity. Involved in several processes, including positive regulation of canonical NF-kappaB signal transduction; response to tumor necrosis factor; and response to type II interferon. Located in cytoplasm and nucleus. Is expressed in alimentary system; aorta; male reproductive gland or organ; olfactory lobe; and thymus. Orthologous to human UBD (ubiquitin D). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ubd |
| Official Name | ubiquitin D [Source:MGI Symbol;Acc:MGI:1344410] |
| Ensembl ID | ENSMUSG00000035186 |
| Bio databases IDs | |
| Aliases | ubiquitin D |
| Synonyms | DIUBIQUITIN, FAT10, UBD-3, Ubiquitin d |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ubd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin family
- diglycine motif
- binding protein
- Ubl1_cv_Nsp3_N-like
- Ubiquitin homologues
- protein binding
Pathways
Biological processes and signaling networks where the Ubd gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- organismal death
- colorectal cancer
- kidney disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- pancreatic cancer
- pancreatic adenocarcinoma
role in cell
- quantity
- proliferation
- expression in
- migration
- apoptosis
- phosphorylation in
- function
- activation in
- cell viability
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- aggresome
- fibrillar center
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ubd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- myeloid dendritic cell differentiation
- response to interferon-gamma
- proteolysis
- positive regulation of apoptotic process
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- aggresome assembly
- protein ubiquitination
- protein modification by small protein conjugation
- ubiquitin-dependent protein catabolic process
- response to tumor necrosis factor
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- aggresome
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- proteasome binding