Mis12 Gene Summary [Mouse]
Predicted to be involved in attachment of mitotic spindle microtubules to kinetochore and kinetochore assembly. Predicted to be located in kinetochore and nucleus. Predicted to be part of MIS12/MIND type complex. Orthologous to human MIS12 (MIS12 kinetochore complex component). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mis12 |
| Official Name | MIS12 kinetochore complex component [Source:MGI Symbol;Acc:MGI:1914389] |
| Ensembl ID | ENSMUSG00000040599 |
| Bio databases IDs | |
| Aliases | MIS12 kinetochore complex component |
| Synonyms | 2510025F08Rik, hMis12, KNTC2AP, MIS12 kinetochore complex component, Misc12, MTW1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mis12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Mis12 protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- kinetochores
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mis12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- attachment of spindle microtubules to kinetochore
- mitotic sister chromatid segregation
- chromosome segregation
- kinetochore assembly
- attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation
Cellular Component
Where in the cell the gene product is active
- nucleus
- spindle pole
- cytosol
- kinetochore
- MIS12/MIND type complex
Molecular Function
What the gene product does at the molecular level
- protein binding